Release date: December 23, 2020
Number of genes inferred from genetic manipulations: 279
Number of genes from expression changes: 1,259
This is the second build of the CellAge database of cell senescence genes. It consists of a manually-curated collection of human genes associated with cellular senescence in vitro plus a gene expression signature of replicative senescence derived from a meta-analysis of human microarray data.
Please remember these notes refer to the latest stable build of CellAge. The current CellAge stats may differ slightly from the above due to improvements after the build's release.
More information concerning the design and curation of CellAge is available elsewhere. Use of the CellAge is free but subject to the conditions of the Human Ageing Genomic Resources. To cite CellAge please use:
Avelar, R. A., Ortega, J. G., Tacutu, R., Tyler, E. J., Bennett, D., Binetti, P., Budovsky, A., Chatsirisupachai, K., Johnson, E., Murray, A., Shields, S., Tejada-Martinez, D., Thornton, D., Fraifeld, V. E., Bishop, C. L., & de Magalhaes, J. P. (2020) "A multidimensional systems biology analysis of cellular senescence in aging and disease." Genome Biology 21(1):91.
If you only use the gene expression signature of cellular senescence, please cite:
Chatsirisupachai, K., Palmer, D., Ferreira, S., & de Magalhaes, J. P. (2019) "A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence." Aging Cell 18(6):e13041.
Comments, suggestions, ideas, and bug reports are welcome. Please contact us.