LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Italian (Northern and Central)
Study Design
-511 C/T SNP was examined in 1131 unrelated individuals aged 20-102 years (453 females and 678 males, including 94 female and 40 male centenarians)
Conclusions
No significant differences in the genotype and allele frequency distributions were observed between young, elderly and centenarian subjects
Identifier
-511C/T
In Other Studies (IDs)
201
Cytogenetic Location
2q14.1
UCSC Genome Browser
View 2q14.1 on the UCSC genome browser

Gene details

HGNC symbol
IL1B
Aliases
IL-1; IL1F2; IL1-BETA 
Common name
interleukin 1 beta 
Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
147720
Ensembl
ENSG00000125538
UniProt/Swiss-Prot
IL1B_HUMAN
Entrez Gene
3553
UniGene
126256
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
il1b
Mus musculus
Il1b
Rattus norvegicus
Il1b

References

Cavallone et al. (2003)

Other variants which are also part of this study