LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- The I405V polymorphism distribution was examined in 213 Ashkenazi Jews with exceptional longevity (mean [SD] age, 98.2 [5.3] years), their offspring (n = 216; mean [SD] age, 68.3 [6.7] years) and in an age-matched control group of Ashkenazi Jews (n = 258) plus in participants from the Framingham Offspring Study (n = 589)
- Conclusions
- Probands with exceptional longevity showed an increased frequency of homozygosity for the 405 valine allele (VV genotype) compared with controls
- Identifier
- I405V
- In Other Studies (IDs)
- 185 385
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
Gene details
- HGNC symbol
- CETP
- Aliases
- BPIFF; HDLCQ10
- Common name
- cholesteryl ester transfer protein
- Description
- The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
- Other longevity studies of this gene
- 17
- OMIM
- 118470
- Ensembl
- ENSG00000087237
- UniProt/Swiss-Prot
- A0A0S2Z3F6_HUMAN
- Entrez Gene
- 1071
- UniGene
- 89538
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- cetp
In other databases
- GenAge human genes
- This gene is present as CETP