LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Bulgarian
- Study Design
- -174G/C SNP was examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls
- Conclusions
- GC genotype was higher in elders while GG genotype was lower in elders, though differences were not statistically significant after correcting for multiple testing
Gene details
- HGNC symbol
- IL6
- Aliases
- CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
- Common name
- interleukin 6
- Description
- This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- Other longevity studies of this gene
- 19
- OMIM
- 147620
- Ensembl
- ENSG00000136244
- UniProt/Swiss-Prot
- B4DNQ5_HUMAN
- Entrez Gene
- 3569
- UniGene
- 654458
- HapMap
- View on HapMap