LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- CA repeat (promoter) and CT repeat (intron 2) were examined in 1576 individuals aged >85
- Conclusions
- CA repeats (191 bp minor allele) seem to contribute most to female longevity, though this was not statistically significant
- Identifier
- IGF1
- In Other Studies (IDs)
- 232 241
- Cytogenetic Location
- 12q23.2
- UCSC Genome Browser
- View 12q23.2 on the UCSC genome browser
Gene details
- HGNC symbol
- IGF1
- Aliases
- MGF; IGFI; IGF-I
- Common name
- insulin like growth factor 1
- Description
- The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
- Other longevity studies of this gene
- 9
- OMIM
- 147440
- Ensembl
- ENSG00000017427
- UniProt/Swiss-Prot
- IGF1_HUMAN
- Entrez Gene
- 3479
- UniGene
- 160562
- HapMap
- View on HapMap