LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Italian (Northern)
Study Design: Polymorphisms were examined in 94 nonagenarians and centenarians and 418 control subjects of younger age
Conclusions: No association with longevity was found

HGNC symbol: CYP1A1
Aliases: AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
Common name: cytochrome P450 family 1 subfamily A member 1
Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Other longevity studies of this gene: 2
OMIM: 108330
Ensembl: ENSG00000140465
UniProt/Swiss-Prot: A0N0X8_HUMAN
Entrez Gene: 1543
UniGene: 72912
HapMap: View on HapMap