LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Russian
Study Design
5'-untranslated region (T-455C) SNP was examined in a group of 137 elderly individuals (70-106 years old)
Conclusions
A greater frequency of the -455C allele was demonstrated with aging
Identifier
T-455C
Cytogenetic Location
11q23.3
UCSC Genome Browser
View 11q23.3 on the UCSC genome browser

Gene details

HGNC symbol
APOC3
Aliases
HALP2; APOCIII 
Common name
apolipoprotein C3 
Description
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
7
OMIM
107720
Ensembl
ENSG00000110245
UniProt/Swiss-Prot
A3KPE2_HUMAN
Entrez Gene
345
UniGene
73849
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Apoc3
Rattus norvegicus
Apoc3

In other databases

GenAge human genes
  • This gene is present as APOC3

References

Anisimov et al. (2001)

Other variants which are also part of this study