LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- APOA4-HincII-RFLP (Asp127/Ser127) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years)
- Conclusions
- No significant differences relative to longevity were found
- Identifier
- APOA4-HincII-RFLP
- Cytogenetic Location
- 11q23.3
- UCSC Genome Browser
- View 11q23.3 on the UCSC genome browser
Gene details
- HGNC symbol
- APOA4
- Aliases
- Common name
- apolipoprotein A4
- Description
- Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 107690
- Ensembl
- ENSG00000110244
- UniProt/Swiss-Prot
- Entrez Gene
- 337
- UniGene
- 1247
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found