LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Danish, German, Dutch
- Study Design
- 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
- Conclusions
- The minor allele frequency of rs9923854 in CETP was significantly associated with longevity. Haplotype case–control comparisons identified two haplotypes associated with longevity. Gene-based analysis confirmed the significant association of variations in CETP with longevity. The association of rs9923854 was borderline in the German population.
Variants (8)
1.
- Identifier
- rs5882
- In Other Studies (IDs)
- 667 1948
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
2.
- Identifier
- rs9923854
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
3.
- Identifier
- rs1800777
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
4.
- Identifier
- rs1800774
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
5.
- Identifier
- rs4784744
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
6.
- Identifier
- rs289714
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
7.
- Identifier
- rs5883
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
8.
- Identifier
- rs9930761
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
Gene details
- HGNC symbol
- CETP
- Aliases
- BPIFF; HDLCQ10
- Common name
- cholesteryl ester transfer protein
- Description
- The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
- Other longevity studies of this gene
- 17
- OMIM
- 118470
- Ensembl
- ENSG00000087237
- UniProt/Swiss-Prot
- A0A0S2Z3F6_HUMAN
- Entrez Gene
- 1071
- UniGene
- 89538
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- cetp
In other databases
- GenAge human genes
- This gene is present as CETP