LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- Germany, Italian, Chinese (Han)
- Study Design
- 36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
- Conclusions
- None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.
Variants (32)
- Gene summary:
- No gene (2)
- FOXO1 (17)
- FOXO4 (2)
- FOXO6 (11)
No gene
FOXO1
Gene details
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 30
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- UniProt/Swiss-Prot
- FOXO1_HUMAN
- Entrez Gene
- 2308
- UniGene
- 370666
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
FOXO4
Gene details
- HGNC symbol
- FOXO4
- Aliases
- AFX; AFX1; MLLT7
- Common name
- forkhead box O4
- Description
- This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
- Other longevity studies of this gene
- 5
- OMIM
- 300033
- Ensembl
- ENSG00000184481
- UniProt/Swiss-Prot
- FOXO4_HUMAN
- Entrez Gene
- 4303
- UniGene
- 584654
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- LOC563719
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo4
- Rattus norvegicus
- Foxo4
- Saccharomyces cerevisiae
- FHL1
- Schizosaccharomyces pombe
- sep1