Important notice: The option to search GenAge for genes associated with ageing in humans and mammalian animal models has rendered the list below of genes that appear to modulate mammalian ageing obsolete. Therefore, this list is considered deprecated, will not be updated again, and may be deleted sometime in the future. Users are encouraged to use GenAge's search functions to select genes associated with ageing on a given model system.

Genes that Appear to Modulate Mammalian Ageing

Gene name	Common/alternative name	Phenotype	Primary reference
*Mouse (Mus musculus)*
Brca1 + p53	breast cancer 1, early onset + tumour protector 53	Signs of premature ageing in BRCA1 hypomorphic/p53 heterozygous mice.	Cao et al., 2003
Bub3 + Rae1	budding uninhibited by benzimidazoles 3 homolog, MRNP41	BUB3/RAE1 haploinsufficient mice show signs of premature ageing.	Baker et al., 2006
BubR1	BUB1B	Signs of early onset of ageing in mice with low levels of BubR1.	Baker et al., 2004
C/EBP	CCAAT/enhancer-binding protein	20% increase in lifespan in C/EBP beta/beta mice.	Chiu et al., 2004
GH	growth hormone	Putative accelerated ageing in transgenic mice.	Bartke, 2003
GHR/BP	growth hormone receptor (Laron mouse)	Increase in lifespan of 40-50% in homozygous knock-outs.	Cochigano et al., 2000
klotho		Potential accelerated ageing phenotype of homozygous knock-outs.	Kuro-o et al., 1997
Ku86	XRCC5	Signs of premature ageing due to homozygous mutation.	Vogel et al., 1999
MsrA	methionine sulfoxide reductase A	Decreased lifespan and putative accelerated ageing in homozygous knock-outs.	Moskovitz et al., 2001
p53	tumour protector 53	Heterozygous mutant mice show signs of accelerated ageing.	Tyner et al., 2002
p63	TP73L	Heterozygous mice display signs of premature ageing.	Keyes et al., 2005
p66^shc	SHC1	Roughly 30% increase in lifespan in -/- mice.	Migliaccio et al., 1999
PASG	proliferation associated SNF2-like gene	Phenotypes resembling accelerated ageing due to gene disruption.	Sun et al., 2004
Pit1	Snell dwarf mouse	Lifespan increase of 42% in homozygous mice.	Flurkey et al., 2001
PolgA	mitochondrial DNA polymerase	Possible premature ageing in mice with a defective PolgA.	Trifunovic et al., 2004
Prop1	Ames dwarf mouse	Homozygous mice show over 50% increases in lifespan.	Brown-Borg et al., 1996
SIRT6	sirtuin 6	SIRT6-deficient mice show signs of premature ageing.	Mostoslavsky et al., 2006
Terc + Atm	telomerase RNA component + ataxia telangiectasia mutated	Signs of premature ageing in double mutant mice.	Wong et al., 2003
Terc + WRN	telomerase RNA component + Werner syndrome	Signs of premature ageing in double mutant mice.	Chang et al., 2004
uPA	urokinase-type plasminogen activator	Roughly 20% increase in lifespan of transgenic mice.	Miskin and Masos, 1997
XPD	xeroderma pigmentosum, group D	Symptoms of premature ageing due to homozygous mutation.	de Boer et al., 2002

*Human (Homo sapiens)*
CSA	Cockayne syndrome type I	Possible premature ageing due to recessive mutation.	Henning et al., 1995
WRN	Werner syndrome	Possible accelerated ageing due to recessive mutation.	Yu et al., 1996
LMNA	Hutchinson-Gilford syndrome	Possible premature ageing due to dominant mutation.	Eriksson et al., 2003

Please note: Gene names are in accordance with the primary reference. Also, only one reference per gene is displayed. Please consult the appropriate GenAge entry for additional bibliographical information.