Cell Senescence Entries for MVP

Cell Types
Breast cancer
Cell Lines
MDA-MB-231, MDA-MB-468, SKBR3, T47D, ZR751
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Pasillas et al. (2015) Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics 14(1)1-14 (PubMed)

MVP Gene Information

HGNC symbol
MVP 
Aliases
LRP; VAULT1 
Common name
major vault protein 
Entrez Id
9961
Description
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

MVP Ontologies

Gene Ontology
Process: GO:51028; mRNA transport
GO:15031; protein transport
GO:42059; negative regulation of epidermal growth factor receptor signaling pathway
GO:61099; negative regulation of protein tyrosine kinase activity
GO:38127; ERBB signaling pathway
GO:31953; negative regulation of protein autophosphorylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5643; nuclear pore
GO:48471; perinuclear region of cytoplasm
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:19903; protein phosphatase binding
Hide GO terms

Homologs of MVP in Model Organisms

Danio rerio
mvp
Mus musculus
Mvp
Rattus norvegicus
Mvp

In other databases

GenAge microarray genes
  • This gene is present as MVP

External links

OMIM
605088
Ensembl
ENSG00000013364
Entrez Gene
9961
UniGene
632177
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MVP
GeneCards
MVP