Cell Senescence Entries for MYD88

Cell Types
Breast cancer, Melanoma, Prostate cancer
Cell Lines
M628, MCF-7, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ye et al. (2015) TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. EMBO Mol Med 6(10)1294-311 (PubMed)

MYD88 Gene Information

HGNC symbol
MYD88 
Aliases
 
Common name
MYD88 innate immune signal transduction adaptor 
Entrez Id
4615
Description
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

MYD88 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:50830; defense response to Gram-positive bacterium
GO:6909; phagocytosis
GO:8063; Toll signaling pathway
GO:32731; positive regulation of interleukin-1 beta production
GO:71260; cellular response to mechanical stimulus
GO:1900227; positive regulation of NLRP3 inflammasome complex assembly
GO:10628; positive regulation of gene expression
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:71222; cellular response to lipopolysaccharide
GO:140052; cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017; positive regulation of cytokine production involved in inflammatory response
GO:7166; cell surface receptor signaling pathway
GO:70555; response to interleukin-1
GO:42742; defense response to bacterium
GO:50727; regulation of inflammatory response
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:60337; type I interferon signaling pathway
GO:32747; positive regulation of interleukin-23 production
GO:32740; positive regulation of interleukin-17 production
GO:70935; 3'-UTR-mediated mRNA stabilization
GO:32481; positive regulation of type I interferon production
GO:6915; apoptotic process
GO:34158; toll-like receptor 8 signaling pathway
GO:42832; defense response to protozoan
GO:2238; response to molecule of fungal origin
GO:2269; leukocyte activation involved in inflammatory response
GO:2283; neutrophil activation involved in immune response
GO:7254; JNK cascade
GO:9615; response to virus
GO:9682; induced systemic resistance
GO:10468; regulation of gene expression
GO:16064; immunoglobulin mediated immune response
GO:19221; cytokine-mediated signaling pathway
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:32494; response to peptidoglycan
GO:32496; response to lipopolysaccharide
GO:32675; regulation of interleukin-6 production
GO:32680; regulation of tumor necrosis factor production
GO:32722; positive regulation of chemokine production
GO:32760; positive regulation of tumor necrosis factor production
GO:42127; regulation of cell population proliferation
GO:46330; positive regulation of JNK cascade
GO:48661; positive regulation of smooth muscle cell proliferation
GO:50671; positive regulation of lymphocyte proliferation
GO:70498; interleukin-1-mediated signaling pathway
GO:70944; neutrophil-mediated killing of bacterium
GO:90557; establishment of endothelial intestinal barrier
GO:1902622; regulation of neutrophil migration
GO:2000338; regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341; regulation of chemokine (C-X-C motif) ligand 2 production
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:10008; endosome membrane
GO:14069; postsynaptic density
GO:32991; protein-containing complex
Function: GO:5515; protein binding
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:70976; TIR domain binding
GO:43621; protein self-association
GO:5123; death receptor binding
GO:35325; Toll-like receptor binding
GO:5102; signaling receptor binding
GO:5121; Toll binding
GO:5149; interleukin-1 receptor binding
Hide GO terms

Homologs of MYD88 in Model Organisms

Danio rerio
myd88
Drosophila melanogaster
Myd88
Mus musculus
Myd88
Rattus norvegicus
Myd88

In other databases

GenAge microarray genes
  • This gene is present as MYD88

External links

OMIM
602170
Ensembl
ENSG00000172936
Entrez Gene
4615
UniGene
82116
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYD88
GeneCards
MYD88