Cell Senescence Entries for USP1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ogrunc et al. (2017) RETRACTED: USP1 Regulates Cellular Senescence by Controlling Genomic Integrity. Cell Rep 15(7)1401-1411 (PubMed)

USP1 Gene Information

HGNC symbol
USP1 
Aliases
 
Common name
ubiquitin specific peptidase 1 
Entrez Id
7398
Description
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

USP1 Ontologies

Gene Ontology
Process: GO:16579; protein deubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:6508; proteolysis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:9411; response to UV
GO:1501; skeletal system development
GO:6282; regulation of DNA repair
GO:35520; monoubiquitinated protein deubiquitination
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:4843; thiol-dependent deubiquitinase
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4197; cysteine-type endopeptidase activity
Hide GO terms

Homologs of USP1 in Model Organisms

Danio rerio
usp1
Drosophila melanogaster
BcDNA.LD22910
Mus musculus
Usp1
Rattus norvegicus
Usp1

In other databases

CellAge gene expression
  • This gene is present as USP1

External links

OMIM
603478
Ensembl
ENSG00000162607
Entrez Gene
7398
UniGene
35086
1000 Genomes
1000 Genomes
HPRD
GenAtlas
USP1
GeneCards
USP1