Cell Senescence Entries for HSPA1A

Cell Types
Breast cancer, Cervical cancer, Colorectal cancer
Cell Lines
HCT116, HeLa, MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Yaglom et al. (2007) High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res 67(5)2373-81 (PubMed)

HSPA1A Gene Information

HGNC symbol
HSPA1A 
Aliases
HSP70-1; HSPA1 
Common name
heat shock protein family A (Hsp70) member 1A 
Entrez Id
3303
Description
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].

HSPA1A Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:6986; response to unfolded protein
GO:46718; viral entry into host cell
GO:16192; vesicle-mediated transport
GO:8285; negative regulation of cell population proliferation
GO:6402; mRNA catabolic process
GO:50821; protein stabilization
GO:30308; negative regulation of cell growth
GO:32757; positive regulation of interleukin-8 production
GO:51092; positive regulation of NF-kappaB transcription factor activity
And 28 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:5814; centriole
GO:5739; mitochondrion
GO:5576; extracellular region
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
And 14 more GO terms
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16887; ATP hydrolysis activity
GO:51082; unfolded protein binding
GO:5102; signaling receptor binding
GO:31625; ubiquitin protein ligase binding
GO:45296; cadherin binding
GO:47485; protein N-terminus binding
GO:19899; enzyme binding
And 12 more GO terms
Show all GO terms

Homologs of HSPA1A in Model Organisms

No homologs found

In other databases

GenAge human genes
  • This gene is present as HSPA1A
LongevityMap
  • This gene is present as HSPA1A

External links

OMIM
140550
Ensembl
ENSG00000204389
Entrez Gene
3303
UniGene
702139
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HSPA1A
GeneCards
HSPA1A