Cell Senescence Entries for MYC

Cell Types
Fibroblast
Cell Lines
LF1
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Guney et al. (2006) Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A 103(10)3645-50 (PubMed)

MYC Gene Information

HGNC symbol
MYC 
Aliases
bHLHe39; c-Myc; MYCC 
Common name
MYC proto-oncogene, bHLH transcription factor 
Entrez Id
4609
Description
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].

MYC Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:8150; biological_process
GO:45727; positive regulation of translation
GO:43066; negative regulation of apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6879; cellular iron ion homeostasis
GO:51276; chromosome organization
GO:6338; chromatin remodeling
And 37 more GO terms
Cellular component: GO:5654; nucleoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5791; rough endoplasmic reticulum
GO:5635; nuclear envelope
GO:44195; nucleoplasmic reticulum
GO:5730; nucleolus
GO:5634; nucleus
GO:32991; protein-containing complex
GO:5739; mitochondrion
GO:785; chromatin
And 3 more GO terms
Function: GO:3700; DNA-binding transcription factor activity
GO:3729; mRNA binding
GO:5515; protein binding
GO:71074; eukaryotic initiation factor eIF2 binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:70888; E-box binding
And 5 more GO terms
Show all GO terms

Homologs of MYC in Model Organisms

Danio rerio
myca
Mus musculus
Myc
Rattus norvegicus
Myc

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Myc
GenAge human genes
  • This gene is present as MYC

External links

OMIM
190080
Ensembl
ENSG00000136997
Entrez Gene
4609
UniGene
202453
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYC
GeneCards
MYC