Cell Senescence Entries for MYD88

Cell Types
Breast cancer, Melanoma, Prostate cancer
Cell Lines
M628, MCF-7, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ye et al. (2015) TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. EMBO Mol Med 6(10)1294-311 (PubMed)

MYD88 Gene Information

HGNC symbol
MYD88 
Aliases
 
Common name
MYD88 innate immune signal transduction adaptor 
Entrez Id
4615
Description
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

MYD88 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:50830; defense response to Gram-positive bacterium
GO:6909; phagocytosis
GO:8063; Toll signaling pathway
GO:32731; positive regulation of interleukin-1 beta production
And 48 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:10008; endosome membrane
GO:14069; postsynaptic density
GO:32991; protein-containing complex
Function: GO:5515; protein binding
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:70976; TIR domain binding
GO:43621; protein self-association
GO:5123; death receptor binding
GO:35325; Toll-like receptor binding
GO:5102; signaling receptor binding
GO:5121; Toll binding
GO:5149; interleukin-1 receptor binding
Show all GO terms

Homologs of MYD88 in Model Organisms

Danio rerio
myd88
Drosophila melanogaster
Myd88
Mus musculus
Myd88
Rattus norvegicus
Myd88

In other databases

GenAge microarray genes
  • This gene is present as MYD88

External links

OMIM
602170
Ensembl
ENSG00000172936
Entrez Gene
4615
UniGene
82116
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYD88
GeneCards
MYD88