Cell Senescence Entries for NFE2L2

Cell Types
Lung fibroblast
Cell Lines
HFL1
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kapeta et al. (2010) Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem 285(11)8171-84 (PubMed)

NFE2L2 Gene Information

HGNC symbol
NFE2L2 
Aliases
NRF2 
Common name
nuclear factor, erythroid 2 like 2 
Entrez Id
4780
Description
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].

NFE2L2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:16567; protein ubiquitination
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45088; regulation of innate immune response
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:6357; regulation of transcription by RNA polymerase II
GO:34599; cellular response to oxidative stress
GO:10628; positive regulation of gene expression
GO:45454; cell redox homeostasis
GO:10499; proteasomal ubiquitin-independent protein catabolic process
GO:1903206; negative regulation of hydrogen peroxide-induced cell death
And 39 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5813; centrosome
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:32993; protein-DNA complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:19904; protein domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:1221; transcription coregulator binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
And 1 more GO terms
Show all GO terms

Homologs of NFE2L2 in Model Organisms

Danio rerio
nfe2l2a
Mus musculus
Nfe2l2
Rattus norvegicus
Nfe2l2

In other databases

GenAge human genes
  • This gene is present as NFE2L2

External links

OMIM
600492
Ensembl
ENSG00000116044
Entrez Gene
4780
UniGene
744006
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NFE2L2
GeneCards
NFE2L2