Cell Senescence Entries for PDGFB

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Vindrieux et al. (2013) Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts. Aging (Albany NY) 5(7)531-8 (PubMed)

PDGFB Gene Information

HGNC symbol
PDGFB 
Aliases
SIS; SSV 
Common name
platelet derived growth factor subunit B 
Entrez Id
5155
Description
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

PDGFB Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:45892; negative regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:51781; positive regulation of cell division
GO:8284; positive regulation of cell population proliferation
GO:7507; heart development
GO:72593; reactive oxygen species metabolic process
And 52 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5576; extracellular region
GO:16323; basolateral plasma membrane
GO:5615; extracellular space
GO:62023; collagen-containing extracellular matrix
GO:9986; cell surface
GO:139; Golgi membrane
GO:5788; endoplasmic reticulum lumen
GO:31093; platelet alpha granule lumen
GO:5796; Golgi lumen
And 2 more GO terms
Function: GO:5515; protein binding
GO:8083; growth factor activity
GO:48018; receptor ligand activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:46982; protein heterodimerization activity
GO:5161; platelet-derived growth factor receptor binding
GO:5518; collagen binding
GO:16176; superoxide-generating NADPH oxidase activator activity
GO:42056; chemoattractant activity
GO:48407; platelet-derived growth factor binding
And 2 more GO terms
Show all GO terms

Homologs of PDGFB in Model Organisms

Mus musculus
Pdgfb
Rattus norvegicus
Pdgfb

In other databases

GenAge human genes
  • This gene is present as PDGFB

External links

OMIM
190040
Ensembl
ENSG00000100311
Entrez Gene
5155
UniGene
1976
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PDGFB
GeneCards
PDGFB