Cell Senescence Entries for PIN1
- Cell Types
- Vascular smooth muscle
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Lv et al. (2018) Downregulation of Pin1 in human atherosclerosis and its association with vascular smooth muscle cell senescence. J Vasc Surg 68(3)873-883.e5 (PubMed)
PIN1 Gene Information
- HGNC symbol
- PIN1
- Aliases
- dod
- Common name
- peptidylprolyl cis/trans isomerase, NIMA-interacting 1
- Entrez Id
- 5300
- Description
- Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].
PIN1 Ontologies
- Gene Ontology
-
Process: GO:413; protein peptidyl-prolyl isomerization
GO:7049; cell cycle
GO:1666; response to hypoxia
GO:31647; regulation of protein stability
GO:43547; positive regulation of GTPase activity
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:50821; protein stabilization
GO:32092; positive regulation of protein binding
GO:7088; regulation of mitotic nuclear division
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
And 16 more GO terms Cellular component: GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:36064; ciliary basal body
GO:98978; glutamatergic synapse
GO:30496; midbody
GO:99524; postsynaptic cytosol
Show all GO termsFunction: GO:16853; isomerase activity
GO:3755; peptidyl-prolyl cis-trans isomerase activity
GO:5515; protein binding
GO:48156; tau protein binding
GO:32794; GTPase activating protein binding
GO:8013; beta-catenin binding
GO:31434; mitogen-activated protein kinase kinase binding
GO:50815; phosphoserine residue binding
GO:50816; phosphothreonine residue binding
GO:3774; cytoskeletal motor activity
GO:16859; cis-trans isomerase activity
And 2 more GO terms
Homologs of PIN1 in Model Organisms
- Caenorhabditis elegans
- pinn-1
- Danio rerio
- pin1
- Drosophila melanogaster
- dod
- Mus musculus
- Pin1
- Rattus norvegicus
- LOC364561
- Saccharomyces cerevisiae
- ESS1
- Schizosaccharomyces pombe
- pin1
In other databases
- GenAge human genes
- This gene is present as PIN1
External links
- OMIM
- 601052
- Ensembl
- ENSG00000127445
- Entrez Gene
- 5300
- UniGene
- 465849
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PIN1
- GeneCards
- PIN1