Cell Senescence Entries for PRKDC

Cell Types
Lung cancer
Cell Lines
H460
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Azad et al. (2012) Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. Mol Cancer Res 9(12)1696-707 (PubMed)

PRKDC Gene Information

HGNC symbol
PRKDC 
Aliases
DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1; HYRC; HYRC1; p350; p460; XRCC7 
Common name
protein kinase, DNA-activated, catalytic subunit 
Entrez Id
5591
Description
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

PRKDC Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6303; double-strand break repair via nonhomologous end joining
GO:6310; DNA recombination
GO:2376; immune system process
GO:45087; innate immune response
GO:48511; rhythmic process
GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:1902036; regulation of hematopoietic stem cell differentiation
And 42 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:32991; protein-containing complex
GO:32993; protein-DNA complex
GO:32040; small-subunit processome
GO:70418; DNA-dependent protein kinase complex
And 3 more GO terms
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:19904; protein domain specific binding
And 7 more GO terms
Show all GO terms

Homologs of PRKDC in Model Organisms

Danio rerio
wu:fa96e12
Mus musculus
Prkdc
Rattus norvegicus
Prkdc

In other databases

GenAge human genes
  • This gene is present as PRKDC
LongevityMap
  • This gene is present as PRKDC

External links

OMIM
600899
Ensembl
ENSG00000253729
Entrez Gene
5591
UniGene
491682
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKDC
GeneCards
PRKDC