Cell Senescence Entries for RECQL4
- Cell Types
- Osteosarcoma
- Cell Lines
- U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown, Mutation, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lu et al. (2018) Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. Nat Commun 8(1)2039 (PubMed)
RECQL4 Gene Information
- HGNC symbol
- RECQL4
- Aliases
- RecQ4
- Common name
- RecQ like helicase 4
- Entrez Id
- 9401
- Description
- The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010].
RECQL4 Ontologies
- Gene Ontology
-
Process: GO:6310; DNA recombination
GO:6281; DNA repair
GO:724; double-strand break repair via homologous recombination
GO:723; telomere maintenance
GO:32508; DNA duplex unwinding
GO:6260; DNA replication
GO:6268; DNA unwinding involved in DNA replication
GO:61820; telomeric D-loop disassembly
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5694; chromosome
Show all GO termsFunction: GO:5515; protein binding
GO:3676; nucleic acid binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3678; DNA helicase activity
GO:405; bubble DNA binding
GO:9378; four-way junction helicase activity
GO:32357; oxidized purine DNA binding
And 4 more GO terms
Homologs of RECQL4 in Model Organisms
In other databases
External links
- OMIM
- 603780
- Ensembl
- ENSG00000160957
- Entrez Gene
- 9401
- UniGene
- 31442
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RECQL4
- GeneCards
- RECQL4