Cell Senescence Entries for STAT6

Cell Types
Kidney cancer
Cell Lines
Caki-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kim et al. (2013) Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK. J Biol Chem 288(40)28743-54 (PubMed)

STAT6 Gene Information

HGNC symbol
STAT6 
Aliases
D12S1644; IL-4-STAT 
Common name
signal transducer and activator of transcription 6 
Entrez Id
6778
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

STAT6 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:6357; regulation of transcription by RNA polymerase II
GO:6952; defense response
GO:19221; cytokine-mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:42127; regulation of cell population proliferation
GO:120162; positive regulation of cold-induced thermogenesis
GO:7259; receptor signaling pathway via JAK-STAT
GO:43434; response to peptide hormone
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
And 12 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:45121; membrane raft
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19903; protein phosphatase binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of STAT6 in Model Organisms

Drosophila melanogaster
Stat92E
Mus musculus
Stat6
Rattus norvegicus
Stat6

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Stat92E
GenAge microarray genes
  • This gene is present as STAT6

External links

OMIM
601512
Ensembl
ENSG00000166888
Entrez Gene
6778
UniGene
524518
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAT6
GeneCards
STAT6