Cell Senescence Entries for ZMPSTE24

Cell Types
Umbilical cord blood-derived mesenchymal stem
Cell Lines
HUCB
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Yu et al. (2014) MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24. J Cell Sci 126(Pt 23)5422-31 (PubMed)

ZMPSTE24 Gene Information

HGNC symbol
ZMPSTE24 
Aliases
FACE-1; HGPS; PRO1; STE24; Ste24p 
Common name
zinc metallopeptidase STE24 
Entrez Id
10269
Description
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008].

ZMPSTE24 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:71586; CAAX-box protein processing
GO:50688; regulation of defense response to virus
GO:1889; liver development
GO:1942; hair follicle development
GO:3007; heart morphogenesis
GO:3229; ventricular cardiac muscle tissue development
GO:3231; cardiac ventricle development
GO:3417; growth plate cartilage development
GO:6281; DNA repair
GO:6325; chromatin organization
And 54 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5634; nucleus
GO:5637; nuclear inner membrane
GO:70062; extracellular exosome
GO:30176; integral component of endoplasmic reticulum membrane
GO:32991; protein-containing complex
GO:5635; nuclear envelope
Function: GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:8237; metallopeptidase activity
GO:4222; metalloendopeptidase activity
GO:5515; protein binding
GO:3690; double-stranded DNA binding
GO:4175; endopeptidase activity
GO:8235; metalloexopeptidase activity
Show all GO terms

Homologs of ZMPSTE24 in Model Organisms

Caenorhabditis elegans
fce-1
Danio rerio
zmpste24
Drosophila melanogaster
ste24a
Mus musculus
Zmpste24
Rattus norvegicus
Zmpste24
Saccharomyces cerevisiae
STE24
Schizosaccharomyces pombe
SPAC3H1.05

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Zmpste24
GenAge human genes

External links

OMIM
606480
Ensembl
ENSG00000084073
Entrez Gene
10269
UniGene
721062
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZMPSTE24
GeneCards
ZMPSTE24