GenAge entry for IFNB1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 308)

HGNC symbol: IFNB1
Aliases: IFB; IFF; IFNB; IFN-beta
Common name: Interferon beta

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

IFNB1 is a cytokine signalling protein that belongs to the interferon family (IFN), which acts as part of the innate immune response. IFNB1 is a type I IFN and normally exerts antiproliferative, antiangiogenic, proapoptotic and immunemodulatory functions [4330].

IFNB1 has been shown to be part of the DNA damage response, a process involved in human ageing [4331]. In Terc knockout mice, which normally show accelerated ageing, inactivation of IFNB1 results in the abrogation of progeric phenotypes and extends lifespan. In human and mouse cells the accumulation of DNA damage results in the production of IFNB1 and triggers IFN signalling both in vitro and in vivo [4331]. In addition, inhibition of IFNB1 leads to decreased cell senescence, demonstrating that IFNB1 is a mediator of cell senescence [4331]. Thus, IFN signalling may act as a mechanism that links DNA damage to senescence and premature ageing.

Cytogenetic information

Cytogenetic band: 9p21.3
Location: 21,077,104 bp to 21,077,962 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002250; adaptive immune response
GO:0002286; T cell activation involved in immune response
GO:0002312; B cell activation involved in immune response
GO:0002323; natural killer cell activation involved in immune response
GO:0006959; humoral immune response
GO:0007166; cell surface receptor signaling pathway
GO:0007596; blood coagulation
GO:0009615; response to virus
GO:0030101; natural killer cell activation
GO:0030183; B cell differentiation
GO:0033141; positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458; cellular response to interferon-beta
GO:0042100; B cell proliferation
GO:0042742; defense response to bacterium
GO:0043330; response to exogenous dsRNA
GO:0045071; negative regulation of viral genome replication
GO:0045089; positive regulation of innate immune response
GO:0045343; regulation of MHC class I biosynthetic process
GO:0045581; negative regulation of T cell differentiation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051607; defense response to virus
GO:0060337; type I interferon signaling pathway
GO:0060338; regulation of type I interferon-mediated signaling pathway
GO:0071360; cellular response to exogenous dsRNA
GO:0071549; cellular response to dexamethasone stimulus
GO:0098586; cellular response to virus
GO:2000552; negative regulation of T-helper 2 cell cytokine production
GO:2001235; positive regulation of apoptotic signaling pathway

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space

Function:

GO:0005125; cytokine activity
GO:0005132; type I interferon receptor binding
GO:0008811; chloramphenicol O-acetyltransferase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IFNB1
STRING interaction network

Retrieve sequences for IFNB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Ifnb1
Rattus norvegicus: Ifnb1