Human Ageing-Associated Genes

HAGRID HGNC symbol Common name Display entry Source
1GHRgrowth hormone receptorGHRmammal
2GHRHgrowth hormone releasing hormoneGHRHmammal
3SHC1SHC (Src homology 2 domain containing) transforming protein 1SHC1mammal
4POU1F1POU class 1 homeobox 1POU1F1mammal
5PROP1PROP paired-like homeobox 1PROP1mammal
6TP53tumor protein p53TP53mammal,model,cell
7TERCtelomerase RNA componentTERCmammal,cell
8TERTtelomerase reverse transcriptaseTERTcell,functional
9ATMATM serine/threonine kinaseATMmammal
10PLAUplasminogen activator, urokinasePLAUmammal
11ERCC2excision repair cross-complementation group 2ERCC2mammal
12ERCC8excision repair cross-complementation group 8ERCC8human
13WRNWerner syndrome, RecQ helicase-likeWRNhuman,mammal,cell
14LMNAlamin A/CLMNAhuman
15IGF1Rinsulin-like growth factor 1 receptorIGF1Rmodel
16TXNthioredoxinTXNmodel,functional
17KLklothoKLmammal
19PTPN11protein tyrosine phosphatase, non-receptor type 11PTPN11downstream
20NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)NFKB2functional
21STAT5Bsignal transducer and activator of transcription 5BSTAT5Bdownstream
22STAT3signal transducer and activator of transcription 3 (acute-phase response factor)STAT3downstream
23STAT5Asignal transducer and activator of transcription 5ASTAT5Adownstream
26GH1growth hormone 1GH1mammal,functional,downstream
27IL7Rinterleukin 7 receptorIL7Rputative
28IGF1insulin-like growth factor 1 (somatomedin C)IGF1functional
29IGF2insulin-like growth factor 2IGF2functional
30INSinsulinINSfunctional
31NGFnerve growth factor (beta polypeptide)NGFputative
32IRS1insulin receptor substrate 1IRS1model
33PTPN1protein tyrosine phosphatase, non-receptor type 1PTPN1downstream
34IRS2insulin receptor substrate 2IRS2model,putative
35AKT1v-akt murine thymoma viral oncogene homolog 1AKT1model,cell
36PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaPIK3CBmodel,downstream
37NGFRnerve growth factor receptorNGFRdownstream
38HRASHarvey rat sarcoma viral oncogene homologHRASmodel,cell
39MYCv-myc avian myelocytomatosis viral oncogene homologMYCcell,upstream
40EGFRepidermal growth factor receptorEGFRdownstream
41ERBB2erb-b2 receptor tyrosine kinase 2ERBB2downstream
42INSRinsulin receptorINSRmodel
24NRG1neuregulin 1NRG1putative
46IL2interleukin 2IL2putative
47PDGFBplatelet-derived growth factor beta polypeptidePDGFBupstream
48EGFepidermal growth factorEGFupstream
49IL2RGinterleukin 2 receptor, gammaIL2RGdownstream
50FOSFBJ murine osteosarcoma viral oncogene homologFOSputative
51PDGFRBplatelet-derived growth factor receptor, beta polypeptidePDGFRBdownstream
52EPORErythropoietin receptorEPORdownstream
53SSTsomatostatinSSTupstream
54PRKCDprotein kinase C, deltaPRKCDdownstream
55PPARAperoxisome proliferator-activated receptor alphaPPARAputative
56RETret proto-oncogeneRETdownstream
57PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)PLCG2downstream
58PEX5peroxisomal biogenesis factor 5PEX5functional
25HDAC3histone deacetylase 3HDAC3functional
60PARP1poly (ADP-ribose) polymerase 1PARP1functional,putative
61BRCA1breast cancer 1, early onsetBRCA1mammal
62PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1PIN1upstream
63PTENphosphatase and tensin homologPTENmodel
64CREBBPCREB binding proteinCREBBPupstream
65HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)HIF1Afunctional,downstream
43NCOR1nuclear receptor corepressor 1NCOR1downstream
67RPA1replication protein A1, 70kDaRPA1upstream
68BLMBloom syndrome, RecQ helicase-likeBLMfunctional
69BCL2B-cell CLL/lymphoma 2BCL2functional
70S100BS100 calcium binding protein BS100Bupstream,putative
73IGFBP3insulin-like growth factor binding protein 3IGFBP3upstream
74HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 1HSP90AA1functional
76EGR1early growth response 1EGR1upstream
77VEGFAvascular endothelial growth factor AVEGFAputative
78ABL1ABL proto-oncogene 1, non-receptor tyrosine kinaseABL1functional,downstream
79BRCA2breast cancer 2, early onsetBRCA2functional
80TOP2Atopoisomerase (DNA) II alphaTOP2Afunctional
81TOP2Btopoisomerase (DNA) II betaTOP2Bfunctional
82NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1NFKB1functional
83TOP1topoisomerase (DNA) ITOP1functional
84RAD51RAD51 recombinaseRAD51cell,functional
85UBE2Iubiquitin-conjugating enzyme E2IUBE2Iupstream
86TNFtumor necrosis factorTNFputative
91TGFB1transforming growth factor, beta 1TGFB1putative
92ERCC6excision repair cross-complementation group 6ERCC6functional
93STK11serine/threonine kinase 11STK11upstream
94EP300E1A binding protein p300EP300upstream
96PMLpromyelocytic leukemiaPMLcell,downstream
97GSK3Bglycogen synthase kinase 3 betaGSK3Bdownstream
98HTThuntingtinHTTmammal
99PRKCAprotein kinase C, alphaPRKCAdownstream
100SSTR3somatostatin receptor 3SSTR3downstream
103EEF2eukaryotic translation elongation factor 2EEF2putative
104ERCC3excision repair cross-complementation group 3ERCC3functional
105TERF1telomeric repeat binding factor (NIMA-interacting) 1TERF1functional
106PRKDCprotein kinase, DNA-activated, catalytic polypeptidePRKDCfunctional
107CATcatalaseCATmodel
109ERCC5excision repair cross-complementation group 5ERCC5functional
110ARandrogen receptorARupstream
111GTF2H2general transcription factor IIH, polypeptide 2, 44kDaGTF2H2downstream
112XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)XRCC5mammal
113PCNAproliferating cell nuclear antigenPCNAfunctional
114FEN1flap structure-specific endonuclease 1FEN1downstream
118POLD1polymerase (DNA directed), delta 1, catalytic subunitPOLD1downstream
116TERF2telomeric repeat binding factor 2TERF2functional
117XRCC6X-ray repair complementing defective repair in Chinese hamster cells 6XRCC6functional
199HSPA8heat shock 70kDa protein 8HSPA8functional
119BAXBCL2-associated X proteinBAXdownstream,putative
120RB1retinoblastoma 1RB1cell
121EMDemerinEMDfunctional
122GRB2growth factor receptor-bound protein 2GRB2downstream
123FOXO3forkhead box O3FOXO3model,human_link
124FOXO1forkhead box O1FOXO1model
125HSF1heat shock transcription factor 1HSF1model
126XPAxeroderma pigmentosum, complementation group AXPAfunctional,putative
127MSRAmethionine sulfoxide reductase AMSRAmammal,model
128RECQL4RecQ helicase-like 4RECQL4functional
129SOD2superoxide dismutase 2, mitochondrialSOD2mammal,model
130SOD1superoxide dismutase 1, solubleSOD1model
131FOXM1forkhead box M1FOXM1functional
132COQ7coenzyme Q7 homolog, ubiquinone (yeast)COQ7model
133CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunitCACNA1Aputative
134LRP2low density lipoprotein receptor-related protein 2LRP2downstream
135AIFM1apoptosis-inducing factor, mitochondrion-associated, 1AIFM1functional
136UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)UCHL1putative
137APPamyloid beta (A4) precursor proteinAPPputative
138APOEapolipoprotein EAPOEhuman_link
139A2Malpha-2-macroglobulinA2Mputative
141PRDX1peroxiredoxin 1PRDX1functional,putative
142PON1paraoxonase 1PON1putative
144IL6interleukin 6IL6putative
145RGNregucalcinRGNputative
146ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunitATP5Omodel
147RAD52RAD52 homolog, DNA repair proteinRAD52cell,functional
148TOP3Btopoisomerase (DNA) III betaTOP3Bfunctional,putative
149ERCC1excision repair cross-complementation group 1ERCC1mammal,functional
150SIRT1sirtuin 1SIRT1mammal,model,cell
151HDAC1histone deacetylase 1HDAC1functional
153GPX1glutathione peroxidase 1GPX1functional
154GSRglutathione reductaseGSRfunctional
155GSSglutathione synthetaseGSSfunctional
156GSTA4glutathione S-transferase alpha 4GSTA4functional
157GSTP1glutathione S-transferase pi 1GSTP1functional
158MT-CO1mitochondrially encoded cytochrome c oxidase IMT-CO1cell,functional
159HSPD1heat shock 60kDa protein 1 (chaperonin)HSPD1functional
160HSPA1Aheat shock 70kDa protein 1AHSPA1Amammal,model,functional,putative
161HSPA1Bheat shock 70kDa protein 1BHSPA1Bfunctional,putative
162PCMT1protein-L-isoaspartate (D-aspartate) O-methyltransferasePCMT1functional,putative
163MAPK8mitogen-activated protein kinase 8MAPK8model
164YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zetaYWHAZdownstream
165PTK2Bprotein tyrosine kinase 2 betaPTK2Bdownstream
166PTK2protein tyrosine kinase 2PTK2downstream
167IL7interleukin 7IL7putative
168MAPK14mitogen-activated protein kinase 14MAPK14cell,functional
169FGFR1fibroblast growth factor receptor 1FGFR1putative
170SP1Sp1 transcription factorSP1upstream
171FLT1fms-related tyrosine kinase 1FLT1downstream
172JUNjun proto-oncogeneJUNupstream
173MED1mediator complex subunit 1MED1putative
174MAPK9mitogen-activated protein kinase 9MAPK9model
175MAPK3mitogen-activated protein kinase 3MAPK3downstream
176HMGB1high mobility group box 1HMGB1downstream
177CCNA2cyclin A2CCNA2downstream
178HMGB2high mobility group box 2HMGB2downstream
179MAP3K5mitogen-activated protein kinase kinase kinase 5MAP3K5downstream
115FASFas cell surface death receptorFASputative
181LMNB1lamin B1LMNB1functional
182SDHCsuccinate dehydrogenase complex, subunit C, integral membrane protein, 15kDaSDHCmodel
183FOXO4forkhead box O4FOXO4model
184HESX1HESX homeobox 1HESX1upstream
185PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)PIK3R1downstream
186BSCL2Berardinelli-Seip congenital lipodystrophy 2 (seipin)BSCL2putative
187AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2AGPAT2putative
188BMI1BMI1 proto-oncogene, polycomb ring fingerBMI1putative
189EEF1A1eukaryotic translation elongation factor 1 alpha 1EEF1A1model
190TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)TFAP2Aupstream
191BDNFbrain-derived neurotrophic factorBDNFputative
192CREB1cAMP responsive element binding protein 1CREB1upstream,putative
193ATF2activating transcription factor 2ATF2downstream
194TBPTATA box binding proteinTBPupstream
195APEX1APEX nuclease (multifunctional DNA repair enzyme) 1APEX1functional
196HBP1HMG-box transcription factor 1HBP1downstream
215JAK2Janus kinase 2JAK2downstream
198PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)PTGS2putative
152HSPA9heat shock 70kDa protein 9 (mortalin)HSPA9model
200SIN3ASIN3 transcription regulator family member ASIN3Aputative
201CDK1cyclin-dependent kinase 1CDK1downstream
202TFDP1transcription factor Dp-1TFDP1cell,downstream
18E2F1E2F transcription factor 1E2F1cell,downstream
206CTGFconnective tissue growth factorCTGFputative
207HDAC2histone deacetylase 2HDAC2functional,upstream
208MAXMYC associated factor XMAXfunctional
209MXD1MAX dimerization protein 1MXD1functional
210MDM2MDM2 proto-oncogene, E3 ubiquitin protein ligaseMDM2upstream
180TAF1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDaTAF1downstream
204POLA1polymerase (DNA directed), alpha 1, catalytic subunitPOLA1cell
203DDIT3DNA-damage-inducible transcript 3DDIT3putative
143RELAv-rel avian reticuloendotheliosis viral oncogene homolog ARELAfunctional
71VCPvalosin containing proteinVCPdownstream
66UBBubiquitin BUBBputative
59TCF3transcription factor 3TCF3putative
45JUNDjun D proto-oncogeneJUNDmammal,putative
90MXI1MAX interactor 1, dimerization proteinMXI1putative
44NBNnibrinNBNfunctional,putative
211SUMO1small ubiquitin-like modifier 1SUMO1upstream
212H2AFXH2A histone family, member XH2AFXfunctional
213HOXB7homeobox B7HOXB7putative
75NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)NR3C1downstream
214HOXC4homeobox C4HOXC4putative
101HELLShelicase, lymphoid-specificHELLSmammal
72POLGpolymerase (DNA directed), gammaPOLGmammal
197BUB1BBUB1 mitotic checkpoint serine/threonine kinase BBUB1Bmammal
140SNCGsynuclein, gamma (breast cancer-specific protein 1)SNCGupstream
95APTXaprataxinAPTXfunctional
88CEBPACCAAT/enhancer binding protein (C/EBP), alphaCEBPAfunctional
89CEBPBCCAAT/enhancer binding protein (C/EBP), betaCEBPBmammal
216ESR1estrogen receptor 1ESR1upstream
217LEPleptinLEPputative
218LEPRleptin receptorLEPRputative
219NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaNFKBIAmammal,putative
220CLUclusterinCLUmodel,putative
221MTORmechanistic target of rapamycin (serine/threonine kinase)MTORmammal,model,cell
222GHRHRgrowth hormone releasing hormone receptorGHRHRupstream,putative
223CTNNB1catenin (cadherin-associated protein), beta 1, 88kDaCTNNB1downstream
224PSEN1presenilin 1PSEN1putative
225DLL3delta-like 3 (Drosophila)DLL3putative
226CDKN2Acyclin-dependent kinase inhibitor 2ACDKN2Amammal,cell
228DBN1drebrin 1DBN1putative
229NOGnogginNOGputative
230ELNelastinELNhuman_link
227PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozymePPP1CAcell,putative
205MAPTmicrotubule-associated protein tauMAPTputative
232UCP3uncoupling protein 3 (mitochondrial, proton carrier)UCP3functional
233ZMPSTE24zinc metallopeptidase STE24ZMPSTE24upstream,putative
234TP63tumor protein p63TP63mammal
235UCP2uncoupling protein 2 (mitochondrial, proton carrier)UCP2model
236POLBpolymerase (DNA directed), betaPOLBfunctional
237GCLCglutamate-cysteine ligase, catalytic subunitGCLCfunctional
238GCLMglutamate-cysteine ligase, modifier subunitGCLMmodel
239SIRT6sirtuin 6SIRT6mammal
240BUB3BUB3 mitotic checkpoint proteinBUB3mammal
241RAE1ribonucleic acid export 1RAE1mammal
242PMCHpro-melanin-concentrating hormonePMCHfunctional
87PDPK13-phosphoinositide dependent protein kinase 1PDPK1downstream
231ATRATR serine/threonine kinaseATRmammal
243MLH1mutL homolog 1MLH1functional,putative
102APOC3apolipoprotein C-IIIAPOC3putative
244CSNK1Ecasein kinase 1, epsilonCSNK1Eputative
245STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligaseSTUB1mammal
246PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent, 1DPPM1Ddownstream,putative
247CHEK2checkpoint kinase 2CHEK2functional
248PCK1phosphoenolpyruvate carboxykinase 1 (soluble)PCK1putative
249ARHGAP1Rho GTPase activating protein 1ARHGAP1mammal
250CDC42cell division cycle 42CDC42cell,downstream
251ARNTLaryl hydrocarbon receptor nuclear translocator-likeARNTLmammal
252CLOCKclock circadian regulatorCLOCKfunctional,downstream
253HIC1hypermethylated in cancer 1HIC1upstream
254PAPPApregnancy-associated plasma protein A, pappalysin 1PAPPAmammal,functional,putative
255ADCY5adenylate cyclase 5ADCY5mammal
256PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaPPARGC1Amammal,upstream,downstream
257GPX4glutathione peroxidase 4GPX4putative
258UCP1uncoupling protein 1 (mitochondrial, proton carrier)UCP1putative
259FGF23fibroblast growth factor 23FGF23downstream,putative
260EFEMP1EGF containing fibulin-like extracellular matrix protein 1EFEMP1mammal
261ERCC4excision repair cross-complementation group 4ERCC4functional,putative
262CETPcholesteryl ester transfer protein, plasmaCETPhuman_link
263PPARGperoxisome proliferator-activated receptor gammaPPARGfunctional
264AGTR1angiotensin II receptor, type 1AGTR1mammal
265CISD2CDGSH iron sulfur domain 2CISD2mammal
266EEF1E1eukaryotic translation elongation factor 1 epsilon 1EEF1E1mammal
267EPS8epidermal growth factor receptor pathway substrate 8EPS8mammal
268KCNA3potassium channel, voltage gated shaker related subfamily A, member 3KCNA3mammal
269SIRT7sirtuin 7SIRT7functional,putative
270SLC13A1solute carrier family 13 (sodium/sulfate symporter), member 1SLC13A1mammal,model
271SOCS2suppressor of cytokine signaling 2SOCS2functional,upstream
273TPP2tripeptidyl peptidase IITPP2mammal
274TP53BP1tumor protein p53 binding protein 1TP53BP1functional
275SIRT3sirtuin 3SIRT3functional
276NCOR2nuclear receptor corepressor 2NCOR2mammal
277SUN1Sad1 and UNC84 domain containing 1SUN1upstream
278BAK1BCL2-antagonist/killer 1BAK1functional
279IGFBP2insulin-like growth factor binding protein 2, 36kDaIGFBP2mammal,functional
280PYCR1pyrroline-5-carboxylate reductase 1PYCR1putative
281TP73tumor protein p73TP73functional,putative
282CNR1cannabinoid receptor 1 (brain)CNR1putative
283NFE2L2nuclear factor, erythroid 2-like 2NFE2L2cell,upstream
284CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)CDKN1Acell
285PDGFRAplatelet-derived growth factor receptor, alpha polypeptidePDGFRAdownstream
286PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alphaPIK3CAupstream
287C1QAcomplement component 1, q subcomponent, A chainC1QAupstream
288CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)CDKN2Bcell
289EIF5A2eukaryotic translation initiation factor 5A2EIF5A2mammal
290MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)MIFmammal
291DGAT1diacylglycerol O-acyltransferase 1DGAT1mammal
292MT1Emetallothionein 1EMT1Eputative
293FGF21fibroblast growth factor 21FGF21mammal
294HTRA2HtrA serine peptidase 2HTRA2mammal
295GSK3Aglycogen synthase kinase 3 alphaGSK3Amammal
296NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 1NUDT1mammal
297IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaIKBKBmammal
298SQSTM1sequestosome 1SQSTM1putative
299CDK7cyclin-dependent kinase 7CDK7mammal
300GRNgranulinGRNputative
301SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1SERPINE1upstream
302SPRTNSprT-like N-terminal domainSPRTNputative
303RICTORRPTOR independent companion of MTOR, complex 2RICTORfunctional,putative
304CTF1cardiotrophin 1CTF1putative
306TRPV1transient receptor potential cation channel subfamily V member 1TRPV1mammal
307NFE2L1nuclear factor, erythroid 2-like 1NFE2L1model,functional
305TRAP1TNF receptor-associated protein 1TRAP1functional,putative
308IFNB1Interferon betaIFNB1mammal,cell
309GDF11growth differentiation factor 11GDF11mammal,human_link