GenAge entry for ATP5O (Homo sapiens)

Gene name (HAGRID: 146)

HGNC symbol: ATP5O
Aliases: OSCP; ATPO
Common name: ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: ATP5O is a mitochondrial protein, part of the proton-transporting complex. It has been linked to ageing in lower organisms. In roundworms, lowering the activity of an ATP5O homologue during larval stages, but not during adulthood, extends lifespan [183]. Its involvement in mammalian ageing, however, is not known.

Cytogenetic information

Cytogenetic band: 21q22.11
Location: 33,903,453 bp to 33,915,854 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006754; ATP biosynthetic process
GO:0015992; proton transport
GO:0042776; mitochondrial ATP synthesis coupled proton transport

Cellular component:

GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005753; mitochondrial proton-transporting ATP synthase complex
GO:0005886; plasma membrane
GO:0031012; extracellular matrix
GO:0070062; extracellular exosome

Function:

GO:0005215; transporter activity
GO:0005515; protein binding
GO:0008144; drug binding
GO:0016887; ATPase activity
GO:0022857; transmembrane transporter activity
GO:0046933; proton-transporting ATP synthase activity, rotational mechanism

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: APP, ATF2
STRING interaction network

Retrieve sequences for ATP5O

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: atp-3
Danio rerio: atp5o
Drosophila melanogaster: Oscp
Mus musculus: Atp5o
Rattus norvegicus: Atp5o
Saccharomyces cerevisiae: ATP5
Schizosaccharomyces pombe: atp5

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as atp-3