GenAge entry for BUB3 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 240)

HGNC symbol: BUB3
Aliases: BUB3L
Common name: BUB3 mitotic checkpoint protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: BUB3 is a mitotic spindle checkpoint gene encoding different isoforms. Haploinsufficiency of both BUB3 and RAE1 in mice, but not haploinsufficiency of either gene by itself, reduces lifespan and appears to accelerate ageing [1594]. BUB3-null mice are embryonic lethal [1595].

Cytogenetic information

Cytogenetic band: 10q26
Location: 123,154,244 bp to 123,165,370 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000070; mitotic sister chromatid segregation
GO:0007062; sister chromatid cohesion
GO:0007094; mitotic spindle assembly checkpoint
GO:0008608; attachment of spindle microtubules to kinetochore
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051301; cell division
GO:0051321; meiotic cell cycle
GO:0051436; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

And 2 more GO terms

Cellular component:

GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0005654; nucleoplasm
GO:0005829; cytosol
GO:0033597; mitotic checkpoint complex
GO:1990298; bub1-bub3 complex

Function:

GO:0005515; protein binding
GO:0043130; ubiquitin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, PARP1, RPA1, TOP1, HDAC1, APEX1, BUB1B, HDAC2
STRING interaction network

Retrieve sequences for BUB3

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: bub-3
Danio rerio: bub3
Drosophila melanogaster: Bub3
Mus musculus: Bub3
Schizosaccharomyces pombe: bub3

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Bub3
A homolog of this gene for Caenorhabditis elegans is present as bub-3

CellAge gene expression

This gene is present as BUB3