GenAge entry for DLL3 (Homo sapiens)
Gene name (HAGRID: 225)
- HGNC symbol
- DLL3
- Aliases
- SCDO1
- Common name
- delta-like 3 (Drosophila)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
DLL3 is a member of the Notch pathway involved in development. In mice, Notch signalling, including DLL3, has been linked to regeneration in the liver [1385]. DLL3 has also been linked to development and neurogenesis. Mutations in DLL3 have been associated with developmental defects, but not ageing. The Pudgy (pu) mice phenotype of severe vertebral and rib deformities is caused by a mutation in DLL3 [1388]. Mutations in the human DDL3 gene cause axial skeletal defects [1390]. It is unclear whether DLL3 plays a role in human ageing but it could be part of age-related changes in regenerative ability [1386].
Cytogenetic information
- Cytogenetic band
- 19q13
- Location
- 39,498,917 bp to 39,508,481 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001501; skeletal system development
GO:0001756; somitogenesis
GO:0007219; Notch signaling pathway
GO:0007386; compartment pattern specification
GO:0048339; paraxial mesoderm development
GO:0050768; negative regulation of neurogenesis
Cellular component: GO:0016021; integral component of membrane
Show all GO termsFunction: GO:0005112; Notch binding
GO:0005509; calcium ion binding
Protein interactions and network
No interactions in records.