GenAge entry for EPS8 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 267)

HGNC symbol
EPS8 
Aliases
 
Common name
epidermal growth factor receptor pathway substrate 8 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

EPS8 knockout mice appear to be caloric restricted, most probably due to an impaired fat absorption, and show a lean phenotype and increased lifespan [2158]. EPS8 was also shown to be involved in several type of cancer [2161].

Cytogenetic information

Cytogenetic band
12p12.3
Location
15,620,141 bp to 15,789,576 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007165; signal transduction
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0008283; cell proliferation
GO:0008344; adult locomotory behavior
GO:0008360; regulation of cell shape
GO:0009967; positive regulation of signal transduction
GO:0010458; exit from mitosis
GO:0016601; Rac protein signal transduction
GO:0030832; regulation of actin filament length
GO:0031532; actin cytoskeleton reorganization
GO:0036336; dendritic cell migration
GO:0048149; behavioral response to ethanol
GO:0051016; barbed-end actin filament capping
GO:0051017; actin filament bundle assembly
GO:0051764; actin crosslink formation
GO:0070358; actin polymerization-dependent cell motility
Cellular component: GO:0005903; brush border
GO:0005938; cell cortex
GO:0014069; postsynaptic density
GO:0017146; NMDA selective glutamate receptor complex
GO:0030054; cell junction
GO:0030426; growth cone
GO:0031982; vesicle
GO:0032420; stereocilium
GO:0032587; ruffle membrane
GO:0070062; extracellular exosome
Function: GO:0003779; actin binding
GO:0005070; SH3/SH2 adaptor activity
GO:0005515; protein binding
GO:0048365; Rac GTPase binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, NFKB2, EGFR, XRCC6, GRB2, EPS8
STRING interaction network
Protein-Protein network diagram for EPS8

Retrieve sequences for EPS8

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
eps8
Mus musculus
Eps8
Rattus norvegicus
Eps8

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Eps8

Selected references

External links

EPD
ORF Accession
NM_004447
CDS Accession
NP_004438
OMIM
600206
HPRD
02563
Ensembl
EPS8
UniProt/Swiss-Prot
ES8L2_HUMAN
GeneCards
EPS8
Entrez Gene
2059
UniGene
591160
GenAtlas
EPS8
Internet
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