GenAge entry for GCLC (Homo sapiens)

Gene name (HAGRID: 237)

HGNC symbol: GCLC
Aliases: GCS; GLCLC; GLCL
Common name: glutamate-cysteine ligase, catalytic subunit

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLC in fruit flies extended their mean lifespan by 24% [1551]. In humans, mutations in GCLC have been related to hemolytic anemia [1553] and susceptibility to myocardial infarction [1554].

Cytogenetic information

Cytogenetic band: 6p12
Location: 53,497,341 bp to 53,545,129 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0009408; response to heat
GO:0009410; response to xenobiotic stimulus
GO:0009725; response to hormone
GO:0014823; response to activity
GO:0019852; L-ascorbic acid metabolic process
GO:0031397; negative regulation of protein ubiquitination
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869; cellular response to insulin stimulus
GO:0035729; cellular response to hepatocyte growth factor stimulus
GO:0043066; negative regulation of apoptotic process
GO:0043524; negative regulation of neuron apoptotic process
GO:0044344; cellular response to fibroblast growth factor stimulus
GO:0044752; response to human chorionic gonadotropin
GO:0045454; cell redox homeostasis
GO:0045892; negative regulation of transcription, DNA-templated
GO:0046685; response to arsenic-containing substance
GO:0046686; response to cadmium ion
GO:0050880; regulation of blood vessel size
GO:0051409; response to nitrosative stress
GO:0051900; regulation of mitochondrial depolarization
GO:0070555; response to interleukin-1
GO:0071260; cellular response to mechanical stimulus
GO:0071333; cellular response to glucose stimulus
GO:0071372; cellular response to follicle-stimulating hormone stimulus
GO:0097069; cellular response to thyroxine stimulus
GO:2000490; negative regulation of hepatic stellate cell activation
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway

Cellular component:

GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex

Function:

GO:0000287; magnesium ion binding
GO:0004357; glutamate-cysteine ligase activity
GO:0005524; ATP binding
GO:0016595; glutamate binding
GO:0043531; ADP binding
GO:0046982; protein heterodimerization activity
GO:0050662; coenzyme binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GCLM
STRING interaction network

Retrieve sequences for GCLC

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gcs-1
Danio rerio: gclc
Drosophila melanogaster: Gclc
Mus musculus: Gclc
Rattus norvegicus: Gclc
Saccharomyces cerevisiae: GSH1
Schizosaccharomyces pombe: gcs1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Gclc

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as GSH1

LongevityMap

This gene is present as GCLC