GenAge entry for GCLM (Homo sapiens)

Gene name (HAGRID: 238)

HGNC symbol
GCLM 
Aliases
GLCLR 
Common name
glutamate-cysteine ligase, modifier subunit 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLM in fruit flies extended mean and maximum lifespan by up to 50% [1551]. In humans, polymorphisms in GCLM have been associated with myocardial infarction [1555].

Cytogenetic information

Cytogenetic band
1p22.1
Location
93,885,200 bp to 93,909,598 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0014823; response to activity
GO:0035229; positive regulation of glutamate-cysteine ligase activity
GO:0035729; cellular response to hepatocyte growth factor stimulus
GO:0035733; hepatic stellate cell activation
GO:0042493; response to drug
GO:0043524; negative regulation of neuron apoptotic process
GO:0044344; cellular response to fibroblast growth factor stimulus
GO:0044752; response to human chorionic gonadotropin
GO:0050880; regulation of blood vessel size
GO:0051409; response to nitrosative stress
GO:0051900; regulation of mitochondrial depolarization
GO:0071333; cellular response to glucose stimulus
GO:0071372; cellular response to follicle-stimulating hormone stimulus
GO:0097069; cellular response to thyroxine stimulus
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
Cellular component: GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex
Function: GO:0004357; glutamate-cysteine ligase activity
GO:0030234; enzyme regulator activity
GO:0035226; glutamate-cysteine ligase catalytic subunit binding
GO:0046982; protein heterodimerization activity
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, GCLC
STRING interaction network
Protein-Protein network diagram for GCLM

Retrieve sequences for GCLM

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
CELE_E01A2.1
Danio rerio
gclm
Drosophila melanogaster
Gclm
Mus musculus
Gclm
Rattus norvegicus
Gclm
Schizosaccharomyces pombe
SPCC737.06c

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Gclm

Selected references

External links

EPD
ORF Accession
NM_002061
CDS Accession
NP_002052
OMIM
601176
HPRD
03106
Ensembl
GCLM
UniProt/Swiss-Prot
GSH0_HUMAN
GeneCards
GCLM
Entrez Gene
2730
UniGene
315562
GenAtlas
GCLM
Internet
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