GenAge entry for GPX4 (Homo sapiens)
Gene name (HAGRID: 257)
- HGNC symbol
- GPX4
- Aliases
- PHGPx; MCSP
- Common name
- glutathione peroxidase 4
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
GPX4 is an antioxidant, in particular involved in the detoxification of oxidative damage to membrane lipids. The median lifespan was slightly (about 7%) but significantly increased in heterozygous knockout mice when compared to controls. Heterozygous knockout mice showed a delayed occurrence of fatal tumor lymphoma as well as increased sensitivity apoptosis induced by oxidative stress [1848].
Cytogenetic information
- Cytogenetic band
- 19p13.3
- Location
- 1,103,926 bp to 1,106,789 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006644; phospholipid metabolic process
GO:0006979; response to oxidative stress
GO:0007275; multicellular organism development
GO:0019372; lipoxygenase pathway
GO:0055114; oxidation-reduction process
GO:0098869; cellular oxidant detoxification
Cellular component: GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome
Show all GO termsFunction: GO:0004602; glutathione peroxidase activity
GO:0047066; phospholipid-hydroperoxide glutathione peroxidase activity
Protein interactions and network
Retrieve sequences for GPX4
Homologs in model organisms
- Caenorhabditis elegans
- R05H10.5
- Danio rerio
- gpx4a
- Drosophila melanogaster
- PHGPx
- Mus musculus
- Gpx4
- Rattus norvegicus
- Gpx4
- Saccharomyces cerevisiae
- GPX1
- Schizosaccharomyces pombe
- gpx1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Gpx4
- LongevityMap
- This gene is present as GPX4