GenAge entry for GSR (Homo sapiens)

Gene name (HAGRID: 154)

HGNC symbol
GSR 
Aliases
 
Common name
glutathione reductase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

GSR is involved in redox regulation and oxidative defence. Overexpression of a GSR homologue in fruit flies extends lifespan in hyperoxia but not in normal conditions [208]. Local overexpression of GSR in the brain of mice results in increased anxiety-like behaviour while inhibition decreased the anxiety-like behaviour [1712]. There is no evidence directly linking GSR to human ageing.

Cytogenetic information

Cytogenetic band
8p21.1
Location
30,678,063 bp to 30,727,969 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0006749; glutathione metabolic process
GO:0015949; nucleobase-containing small molecule interconversion
GO:0045454; cell redox homeostasis
GO:0055114; oxidation-reduction process
GO:0098869; cellular oxidant detoxification
Cellular component: GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0009897; external side of plasma membrane
GO:0070062; extracellular exosome
Function: GO:0004362; glutathione-disulfide reductase activity
GO:0009055; electron carrier activity
GO:0050660; flavin adenine dinucleotide binding
GO:0050661; NADP binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EEF2, AIFM1, GSR, HSPD1
STRING interaction network
Protein-Protein network diagram for GSR

Retrieve sequences for GSR

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gsr-1
Danio rerio
gsr
Mus musculus
Gsr
Rattus norvegicus
Gsr
Saccharomyces cerevisiae
GLR1
Schizosaccharomyces pombe
pgr1

In other databases

LongevityMap
  • This gene is present as GSR

Selected references

External links

EPD
ORF Accession
NM_000637
CDS Accession
NP_000628
OMIM
138300
HPRD
00704
Ensembl
GSR
UniProt/Swiss-Prot
GSHR_HUMAN
GeneCards
GSR
Entrez Gene
2936
UniGene
271510
GenAtlas
GSR
Internet
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