GenAge entry for GTF2H2 (Homo sapiens)
Gene name (HAGRID: 111)
- HGNC symbol
- GTF2H2
- Aliases
- BTF2; TFIIH; BTF2P44; T-BTF2P44; p44
- Common name
- general transcription factor IIH, polypeptide 2, 44kDa
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
GTF2H2 is a component of the core TFIIH basal transcription factor that is involved in DNA repair and transcription [954]. The association of TFIIH with some ageing-related genes, such as ERCC2 [955], suggests GTF2H2 may also play a role in ageing, though further studies are needed to investigate this hypothesis.
Cytogenetic information
- Cytogenetic band
- 5q13.2
- Location
- 70,415,374 bp to 70,447,906 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0002031; G-protein coupled receptor internalization
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006289; nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006362; transcription elongation from RNA polymerase I promoter
And 11 more GO terms Cellular component: GO:0000438; core TFIIH complex portion of holo TFIIH complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005669; transcription factor TFIID complex
GO:0005675; holo TFIIH complex
Show all GO termsFunction: GO:0003676; nucleic acid binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004672; protein kinase activity
GO:0005515; protein binding
GO:0008094; DNA-dependent ATPase activity
GO:0008135; translation factor activity, RNA binding
GO:0008270; zinc ion binding
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0047485; protein N-terminus binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- ERCC2, ERCC8, ERCC3, AR, CDK7
- STRING interaction network
Retrieve sequences for GTF2H2
Homologs in model organisms
No homologs found