GenAge entry for HMGB1 (Homo sapiens)

Gene name (HAGRID: 176)

HGNC symbol: HMGB1
Aliases: HMG3; SBP-1; DKFZp686A04236; HMG1
Common name: high mobility group box 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: HMGB1 has been related to DNA unwinding, stress response, and maintenance of genome stability [793]. HMGB1-null mice die shortly after birth [792]. In mice, HMGB1 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [790], though HMGB1 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 13q12
Location: 30,457,916 bp to 30,465,965 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001773; myeloid dendritic cell activation
GO:0002218; activation of innate immune response
GO:0002407; dendritic cell chemotaxis
GO:0002437; inflammatory response to antigenic stimulus
GO:0002643; regulation of tolerance induction
GO:0002840; regulation of T cell mediated immune response to tumor cell
GO:0006265; DNA topological change
GO:0006309; apoptotic DNA fragmentation
GO:0006310; DNA recombination
GO:0006357; regulation of transcription from RNA polymerase II promoter

And 38 more GO terms

Cellular component:

GO:0000793; condensed chromosome
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005768; endosome
GO:0005793; endoplasmic reticulum-Golgi intermediate compartment
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0017053; transcriptional repressor complex

Function:

GO:0000400; four-way junction DNA binding
GO:0000405; bubble DNA binding
GO:0001530; lipopolysaccharide binding
GO:0001786; phosphatidylserine binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005125; cytokine activity
GO:0005515; protein binding
GO:0008134; transcription factor binding

And 10 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, CREBBP, NR3C1, NFKB1, AR, TERF2, RB1, XPA, RELA, HMGB2, TBP, HSPA8, CDK1, PSEN1, TP73
STRING interaction network

Retrieve sequences for HMGB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Hmgb1
Rattus norvegicus: LOC685520

In other databases

LongevityMap

This gene is present as HMGB1

CellAge

This gene is present as HMGB1

CellAge gene expression

This gene is present as HMGB1