GenAge entry for HOXC4 (Homo sapiens)
Gene name (HAGRID: 214)
- HGNC symbol
- HOXC4
- Aliases
- HOX3; HOX3E
- Common name
- homeobox C4
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
HOXC4 is a member of the homeobox family, also called HOX, crucial in morphogenesis and development [1024]. The expression of many HOX genes, including HOXC4, declines with age, even prior to adulthood [1020]. HOXC4 also interacts with XRCC6 and PRKDC [1017]. An association of HOX genes with longevity has been proposed [1022], though there is no direct evidence linking HOXC4 to human ageing.
Cytogenetic information
- Cytogenetic band
- 12q13.3
- Location
- 54,053,877 bp to 54,056,030 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0009952; anterior/posterior pattern specification
GO:0048562; embryonic organ morphogenesis
GO:0051216; cartilage development
Cellular component: GO:0005634; nucleus
Show all GO termsFunction: GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0043565; sequence-specific DNA binding
GO:0071837; HMG box domain binding
