GenAge entry for HSPA9 (Homo sapiens)

Gene name (HAGRID: 152)

HGNC symbol: HSPA9
Aliases: GRP75; PBP74; mot-2; mthsp75; HSPA9B
Common name: heat shock 70kDa protein 9 (mortalin)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: HSPA9 appears to be involved in apoptosis and maybe cellular proliferation. It could also be a molecular chaperone. Roundworms with extra copies of Hsp70F, a HSPA9 homologue, live about 40% longer than controls [904]. A role for HSPA9 in human ageing has not been established.

Cytogenetic information

Cytogenetic band: 5q31.1
Location: 138,554,882 bp to 138,575,629 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006457; protein folding
GO:0006611; protein export from nucleus
GO:0030218; erythrocyte differentiation
GO:0043066; negative regulation of apoptotic process
GO:0045647; negative regulation of erythrocyte differentiation
GO:1902037; negative regulation of hematopoietic stem cell differentiation

Cellular component:

GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005925; focal adhesion
GO:0031012; extracellular matrix
GO:0042645; mitochondrial nucleoid
GO:0043209; myelin sheath
GO:0070062; extracellular exosome

Function:

GO:0005515; protein binding
GO:0005524; ATP binding
GO:0031625; ubiquitin protein ligase binding
GO:0044822; poly(A) RNA binding
GO:0051082; unfolded protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, AKT1, EGFR, HSP90AA1, GRB2, SOD1, APP, SIRT1, HSPD1, SP1, EEF1A1, HSPA8, H2AFX, CDKN2A, SIRT7, SIRT3, TP73, CDKN1A, SPRTN
STRING interaction network

Retrieve sequences for HSPA9

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: hsp-6
Danio rerio: hspa9
Drosophila melanogaster: Hsc70-5
Mus musculus: Hspa9
Rattus norvegicus: Hspa9
Saccharomyces cerevisiae: ECM10
Schizosaccharomyces pombe: ssp1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as hsp-6

CellAge

This gene is present as HSPA9