GenAge entry for IL2RG (Homo sapiens)

Gene name (HAGRID: 49)

HGNC symbol: IL2RG
Aliases: CD132; SCIDX1; IMD4; CIDX
Common name: interleukin 2 receptor, gamma

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: A crucial component in IL2 signal transduction, IL2RG could be related to the age-associated functional decline in the immune system [369].

Cytogenetic information

Cytogenetic band: Xq13.1
Location: 71,107,406 bp to 71,111,631 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0006955; immune response
GO:0007165; signal transduction
GO:0016032; viral process
GO:0035771; interleukin-4-mediated signaling pathway
GO:0038110; interleukin-2-mediated signaling pathway
GO:0038111; interleukin-7-mediated signaling pathway
GO:0043547; positive regulation of GTPase activity

Cellular component:

GO:0005622; intracellular
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0016020; membrane

Function:

GO:0004911; interleukin-2 receptor activity
GO:0004913; interleukin-4 receptor activity
GO:0004917; interleukin-7 receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005515; protein binding
GO:0019976; interleukin-2 binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, IL2, JAK2
STRING interaction network

Retrieve sequences for IL2RG

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: il2rgb
Mus musculus: Il2rg
Rattus norvegicus: Il2rg