GenAge entry for MT-CO1 (Homo sapiens)
Gene name (HAGRID: 158)
- HGNC symbol
- MT-CO1
- Aliases
- COX1; COI; MTCO1
- Common name
- mitochondrially encoded cytochrome c oxidase I
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
Encoded in the mitochondrial DNA, MT-CO1 catalyses the reduction of oxygen to water. COX1, a homologue of MT-CO1, has been related to longevity in the filamentous fungus Podospora anserina [207]. Mutations in the human MT-CO1 gene have been associated with several diseases, including neurodegenerative diseases [751]. Further research is necessary to understand whether MT-CO1 is involved in human ageing.
Cytogenetic information
- Cytogenetic band
- Location
- 7,444 bp to 7,518 bp
- Orientation
- Unknown
Protein information
- Gene Ontology
-
Process: Cellular component:
Show all GO termsFunction:
Protein interactions and network
Retrieve sequences for MT-CO1
Homologs in model organisms
- Caenorhabditis elegans
- cox-1
- Danio rerio
- mt-co1
- Drosophila melanogaster
- mt:CoI
- Mus musculus
- Mtco1
- Rattus norvegicus
- Mtco1
- Saccharomyces cerevisiae
- COX1
- Schizosaccharomyces pombe
- cox1
Selected references
External links
- EPD
- ORF Accession
- NM_173704
- CDS Accession
- NP_776052
- OMIM
- 516030
- HPRD
- 02469
- Ensembl
- MT-CO1
- UniProt/Swiss-Prot
- COX1_HUMAN
- GeneCards
- MT-CO1
- Entrez Gene
- 4512
- UniGene
- GenAtlas
- MT-CO1
- Internet
- Search Google