GenAge entry for MXD1 (Homo sapiens)
Gene name (HAGRID: 209)
- HGNC symbol
- MXD1
- Aliases
- MAD1; bHLHc58; MAD
- Common name
- MAX dimerization protein 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
MXD1 is involved in apoptosis. It forms with MAX a transcriptional repressor and might antagonize MYC function [886]. There is no evidence directly linking MXD1 to human ageing.
Cytogenetic information
- Cytogenetic band
- 2p13-p12
- Location
- 69,915,041 bp to 69,942,944 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008283; cell proliferation
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
Show all GO termsFunction: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- AKT1, PTEN, APP, HDAC1, SIN3A, HDAC2, MAX
- STRING interaction network
