GenAge entry for MXD1 (Homo sapiens)

Gene name (HAGRID: 209)

HGNC symbol
MXD1 
Aliases
MAD1; bHLHc58; MAD 
Common name
MAX dimerization protein 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

MXD1 is involved in apoptosis. It forms with MAX a transcriptional repressor and might antagonize MYC function [886]. There is no evidence directly linking MXD1 to human ageing.

Cytogenetic information

Cytogenetic band
2p13-p12
Location
69,915,041 bp to 69,942,944 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008283; cell proliferation
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, PTEN, APP, HDAC1, SIN3A, HDAC2, MAX
STRING interaction network
Protein-Protein network diagram for MXD1

Retrieve sequences for MXD1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
mxd1
Mus musculus
Mxd1
Rattus norvegicus
Mxd1

Selected references

External links

EPD
ORF Accession
NM_002357
CDS Accession
NP_002348
OMIM
600021
HPRD
02487
Ensembl
MXD1
UniProt/Swiss-Prot
MAD1_HUMAN
GeneCards
MXD1
Entrez Gene
4084
UniGene
468908
GenAtlas
MXD1
Internet
Search Google