GenAge entry for NFKB2 (Homo sapiens)

Gene name (HAGRID: 20)

HGNC symbol
NFKB2 
Aliases
LYT-10; p52; p105; NF-kB2 
Common name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

NFKB2 is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, even though NFKB2 appears to be related to age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-relation changes in NF-kappa-B have been reported for numerous tissues [261].

Cytogenetic information

Cytogenetic band
10q24
Location
102,395,596 bp to 102,402,529 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002268; follicular dendritic cell differentiation
GO:0002467; germinal center formation
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0007568; aging
GO:0030198; extracellular matrix organization
GO:0032481; positive regulation of type I interferon production
GO:0032496; response to lipopolysaccharide
GO:0034097; response to cytokine
GO:0038061; NIK/NF-kappaB signaling
GO:0045087; innate immune response
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048511; rhythmic process
GO:0048536; spleen development
GO:0051092; positive regulation of NF-kappaB transcription factor activity
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0033257; Bcl3/NF-kappaB2 complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NFKB2, STAT3, VCP, NR3C1, NFKB1, RELA, SP1, NFKBIA, EPS8
STRING interaction network
Protein-Protein network diagram for NFKB2

Retrieve sequences for NFKB2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nfkb2
Mus musculus
Nfkb2
Rattus norvegicus
Nfkb2

In other databases

CellAge
  • This gene is present as NFKB2

Selected references

External links

EPD
ORF Accession
NM_002502
CDS Accession
NP_002493
OMIM
164012
HPRD
01239
Ensembl
NFKB2
UniProt/Swiss-Prot
NFKB2_HUMAN
GeneCards
NFKB2
Entrez Gene
4791
UniGene
73090
GenAtlas
NFKB2
Internet
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