GenAge entry for PMCH (Homo sapiens)
Gene name (HAGRID: 242)
- HGNC symbol
- PMCH
- Aliases
- MCH
- Common name
- pro-melanin-concentrating hormone
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
PMCH is a cyclic neuropeptide that appears to be involved in a number of neuronal functions such as food intake [1599]. PMCH overexpression leads to obesity and insulin (INS) resistance [1598]. In contrast, PMCH null mice are resistant to ageing-associated increases in body weight and INS resistance [1601]. While it is dubious that PMCH is a major factor in ageing, it could play a role in some age-related changes.
Cytogenetic information
- Cytogenetic band
- 12q23.2
- Location
- 102,196,459 bp to 102,197,845 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0007218; neuropeptide signaling pathway
GO:0007268; chemical synaptic transmission
GO:0007275; multicellular organism development
GO:0007283; spermatogenesis
GO:0007631; feeding behavior
GO:0030154; cell differentiation
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
Show all GO termsFunction: GO:0030354; melanin-concentrating hormone activity
Protein interactions and network
No interactions in records.