GenAge entry for POLA1 (Homo sapiens)

Gene name (HAGRID: 204)

HGNC symbol: POLA1
Aliases: p180; POLA; NSX
Common name: polymerase (DNA directed), alpha 1, catalytic subunit

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: POLA1 is involved in DNA replication. In yeast, mutations in POLA1 reduce lifespan [1425]. Age-related changes in POLA1 induction have been shown in rats [580]. Whether POLA1 is involved in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: Xp22.1-p21
Location: 24,693,947 bp to 24,996,985 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000731; DNA synthesis involved in DNA repair
GO:0006260; DNA replication
GO:0006269; DNA replication, synthesis of RNA primer
GO:0006270; DNA replication initiation
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006272; leading strand elongation
GO:0006273; lagging strand elongation
GO:0006281; DNA repair

And 5 more GO terms

Cellular component:

GO:0000785; chromatin
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005658; alpha DNA polymerase:primase complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0016363; nuclear matrix

Function:	GO:0000166; nucleotide binding GO:0001882; nucleoside binding GO:0003677; DNA binding GO:0003682; chromatin binding GO:0003887; DNA-directed DNA polymerase activity GO:0003896; DNA primase activity GO:0005515; protein binding GO:0008408; 3'-5' exonuclease activity GO:0019901; protein kinase binding GO:0046872; metal ion binding GO:0046982; protein heterodimerization activity
	And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, MYC, PARP1, RPA1, XRCC5, PCNA, RB1, CCNA2, CDK1, RAE1, SIRT7
STRING interaction network

Retrieve sequences for POLA1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: CELE_Y47D3A.29
Danio rerio: pola1
Drosophila melanogaster: DNApol-alpha180
Mus musculus: Pola1
Rattus norvegicus: Pola1
Saccharomyces cerevisiae: POL1
Schizosaccharomyces pombe: pol1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as Y47D3A.29

CellAge gene expression

This gene is present as POLA1