GenAge entry for POLB (Homo sapiens)

Gene name (HAGRID: 236)

HGNC symbol
POLB 
Aliases
 
Common name
polymerase (DNA directed), beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

POLB is involved in DNA maintenance, replication, and recombination. It appears to play a role in DNA repair and it interacts with WRN [1520]. In mice, POLB haploinsufficiency increases cancer risk with age. While lifespan is not significantly altered, haploinsufficient mice may exhibit an increase in age-related mortality [1815]. POLB's role, if any, in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
8p11.2
Location
42,338,455 bp to 42,371,813 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006261; DNA-dependent DNA replication
GO:0006281; DNA repair
GO:0006284; base-excision repair
GO:0006286; base-excision repair, base-free sugar-phosphate removal
GO:0006287; base-excision repair, gap-filling
GO:0006288; base-excision repair, DNA ligation
GO:0006290; pyrimidine dimer repair
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006954; inflammatory response
GO:0006974; cellular response to DNA damage stimulus
GO:0007435; salivary gland morphogenesis
GO:0007568; aging
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332; response to gamma radiation
GO:0016446; somatic hypermutation of immunoglobulin genes
GO:0045471; response to ethanol
GO:0048535; lymph node development
GO:0048536; spleen development
GO:0048872; homeostasis of number of cells
GO:0051402; neuron apoptotic process
GO:0055093; response to hyperoxia
GO:0071707; immunoglobulin heavy chain V-D-J recombination
GO:0071897; DNA biosynthetic process
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005874; microtubule
GO:0005876; spindle microtubule
GO:0043234; protein complex
Function: GO:0003684; damaged DNA binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515; protein binding
GO:0008017; microtubule binding
GO:0016829; lyase activity
GO:0019899; enzyme binding
GO:0046872; metal ion binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
WRN, PARP1, EP300, APTX, PCNA, APEX1, STUB1, TPP2
STRING interaction network
Protein-Protein network diagram for POLB

Retrieve sequences for POLB

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
polb
Mus musculus
Polb
Rattus norvegicus
Polb
Saccharomyces cerevisiae
POL4

In other databases

LongevityMap
  • This gene is present as POLB

Selected references

External links

EPD
ORF Accession
NM_002690
CDS Accession
NP_002681
OMIM
174760
HPRD
07517
Ensembl
POLB
UniProt/Swiss-Prot
DPOLB_HUMAN
GeneCards
POLB
Entrez Gene
5423
UniGene
654484
GenAtlas
POLB
Internet
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