GenAge entry for PPM1D (Homo sapiens)
Gene name (HAGRID: 246)
- HGNC symbol
- PPM1D
- Aliases
- Wip1; PP2C-DELTA
- Common name
- protein phosphatase, Mg2+/Mn2+ dependent, 1D
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
PPM1D is upregulated by p53 in response to a number of stresses, such as DNA damage, and behaves as an oncogene. PPM1D-null males, but interestingly not females, showed reduced longevity and body weight and some signs of premature ageing. IGF1 levels were higher in PPM1D-null males until about one year of age yet then declined faster than in controls. PPM1D-null mice were cancer resistant and had an augmented stress response following DNA damage [1837].
Cytogenetic information
- Cytogenetic band
- 17q23.2
- Location
- 60,600,183 bp to 60,666,279 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0006470; protein dephosphorylation
GO:0008285; negative regulation of cell proliferation
GO:0009267; cellular response to starvation
GO:0009314; response to radiation
GO:0009617; response to bacterium
GO:0035970; peptidyl-threonine dephosphorylation
Cellular component: GO:0005634; nucleus
Show all GO termsFunction: GO:0004722; protein serine/threonine phosphatase activity
GO:0005515; protein binding
GO:0046872; metal ion binding
GO:0051019; mitogen-activated protein kinase binding
Protein interactions and network
Retrieve sequences for PPM1D
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Ppm1d
- CellAge
- This gene is present as PPM1D