GenAge entry for SLC13A1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 270)
- HGNC symbol
- SLC13A1
- Aliases
- NaSi-1; NAS1
- Common name
- solute carrier family 13 (sodium/sulfate symporter), member 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
SLC13A1, also known as NaS1, is one of the members of the solute carrier family (sodium/sulfate symporters) and has a role in mediating sulfate reabsorption in the kidney. It appears to be involved in kidney disease.
Knockout NaS1 mice (Nas1 -/- ) were found to live longer and have less tumors in aged mice. Median lifespans was increased in both male and female mice when compared with wild type [2172]. Similar results were observed for orthologs of SLC13A1 in flies [2173] and worm [2174]. Therefore, results from model systems support a role for SLC13A1 in ageing, although further studies are necessary to determine if it also plays a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 7q31.32
- Location
- 123,113,534 bp to 123,199,971 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0008272; sulfate transport
GO:0035725; sodium ion transmembrane transport
GO:1902358; sulfate transmembrane transport
Cellular component: GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
Show all GO termsFunction: GO:0015382; sodium:sulfate symporter activity
Protein interactions and network
No interactions in records.
Retrieve sequences for SLC13A1
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Slc13a1