GenAge entry for SST (Homo sapiens)

Gene name (HAGRID: 53)

HGNC symbol
SST 
Aliases
SMST 
Common name
somatostatin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

Somatostatin is an important regulator of endocrine and nervous system function [386]. It inhibits the release of GH1 probably through GHRH [1568]. Because its levels change with age, it is likely that age-related changes are affected or affect SST [385], and a role for SST in Alzheimer's disease has also been proposed [1664].

Cytogenetic information

Cytogenetic band
3q28
Location
187,668,906 bp to 187,670,413 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006972; hyperosmotic response
GO:0007166; cell surface receptor signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0007268; chemical synaptic transmission
GO:0007584; response to nutrient
GO:0007586; digestion
GO:0008285; negative regulation of cell proliferation
GO:0008628; hormone-mediated apoptotic signaling pathway
GO:0009408; response to heat
GO:0010447; response to acidic pH
And 5 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0043025; neuronal cell body
Function: GO:0005179; hormone activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SSTR3
STRING interaction network
Protein-Protein network diagram for SST

Retrieve sequences for SST

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
sst1.1
Mus musculus
Sst
Rattus norvegicus
Sst

Selected references

External links

EPD
HS_SST
ORF Accession
NM_001048
CDS Accession
NP_001039
OMIM
182450
HPRD
08920
Ensembl
SST
UniProt/Swiss-Prot
SMS_HUMAN
GeneCards
SST
Entrez Gene
6750
UniGene
12409
GenAtlas
SST
Internet
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