GenAge entry for TAF1 (Homo sapiens)
Gene name (HAGRID: 180)
- HGNC symbol
- TAF1
- Aliases
- NSCL2; TAFII250; KAT4; DYT3/TAF1; TAF2A; BA2R; CCG1; CCGS; DYT3
- Common name
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Essential in cell cycle progression, TAF1 is also involved in transcription as part of the TFIID transcription factor together with TBP [891]. There is no direct evidence linking TAF1 to human ageing, but due to TAF1's importance in cell cycle control and its relation with other proteins previously related to ageing, TAF1 might play some role in human ageing.
Cytogenetic information
- Cytogenetic band
- Xq13.1
- Location
- 71,366,239 bp to 71,466,005 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000209; protein polyubiquitination
GO:0006352; DNA-templated transcription, initiation
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006468; protein phosphorylation
GO:0006974; cellular response to DNA damage stimulus
GO:0007049; cell cycle
GO:0008284; positive regulation of cell proliferation
GO:0010629; negative regulation of gene expression
GO:0010767; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
And 25 more GO terms Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005669; transcription factor TFIID complex
GO:0005730; nucleolus
GO:0071339; MLL1 complex
Show all GO termsFunction: GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001075; transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
GO:0001129; RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
GO:0002039; p53 binding
GO:0003713; transcription coactivator activity
GO:0004402; histone acetyltransferase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
GO:0016301; kinase activity
And 8 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ATM, MYC, FOS, UBE2I, AR, RB1, RELA, JUN, TBP, SIN3A, MAX, MDM2
- STRING interaction network
